Premium
Insertion/deletion polymorphism in IL1A 3′‐UTR is associated with susceptibility to endometrial cancer in Chinese Han women
Author(s) -
Yu Xiuzhang,
Zhou Bin,
Zhang Zhu,
Lan Zhu,
Chen Peng,
Duan Ruiqi,
Zhang Lin,
Xi Mingrong
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12989
Subject(s) - medicine , endometrial cancer , polymorphism (computer science) , gynecology , genetics , oncology , cancer , gene , genotype , biology
Aim The aim of this study was to investigate whether a functional insertion/deletion polymorphism (rs3783553) located in the 3′‐untranslated regions of interleukin‐1 A is associated with susceptibility to endometrial cancer (EC) in Chinese Han women. Methods A total of 272 patients and 294 age‐matched healthy controls were included in the study. The genotype of the rs3783553 polymorphism was determined by polymerase chain reaction polyacrylamide gel electrophoresis. Results Our results showed that a significantly reduced risk of EC was found to be associated with the II (insertion/insertion) genotype compared with DD (deletion/deletion) only ( P = 0.037, odds ratio = 0.56, 95% confidence interval = 0.32–0.97) as well as compared with the DD + DI (deletion/insertion) genotype ( P = 0.032, odds ratio = 0.57, 95% confidence interval = 0.34–0.96) in the recessive model. No significant association was detected between certain clinical features of EC patients and genotype of rs3783553. Conclusions This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to EC. The II genotype seems to be a protective factor for EC in Chinese Han women.