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Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra‐epithelial neoplasia
Author(s) -
Atik Yeliz,
Cetinkaya Demir Bilge,
Ozan Hakan,
Baykara Sema,
Usubutun Alp,
Yılmaz Erturk Fatma
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12981
Subject(s) - staining , immunohistochemistry , medicine , pathology , wilms' tumor , adenocarcinoma , endometrium , cancer
Abstract Aim To investigate the expression of Wilms' tumor 1 ( WT1 ) protein in endometrial adenocarcinoma (EC) and endometrial intra‐epithelial neoplasia (EIN). Methods WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative ( n = 7), secretory ( n = 9) and atrophic endometrium ( n = 9) and benign endometrial polyps ( n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. Results Cellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1–3; IQR, 1.75 vs 2, 0–3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. Conclusion WT1 is expressed in EIN.