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Immunoglobulin G4‐related disease presenting as bilateral ovarian masses and mimicking advanced ovarian cancer
Author(s) -
Maruyama Shunsuke,
Sato Yukiyasu,
Taga Atsuko,
Emoto Ikuko,
Shirase Tomoyuki,
Haga Hironori
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12835
Subject(s) - medicine , ovarian cancer , igg4 related disease , pathology , histopathology , lymph node , fibrosis , magnetic resonance imaging , infiltration (hvac) , ovary , adnexal mass , cancer , radiology , physics , thermodynamics
Immunoglobulin G4‐related disease (IgG4‐RD) is characterized by extensive infiltration of IgG4 + plasma cells and fibrosis in various organs. However, the involvement of the ovary in IgG4‐RD has never been reported. A 59‐year‐old woman presented with urinary retention. Magnetic resonance imaging and computed tomography revealed a huge multinodular pelvic mass and common iliac/para‐aortic lymph node swelling. A laparotomy was performed under the suspicion of advanced ovarian cancer, and the pelvic mass was identified as ovary in origin. Histopathology of the excised tumor revealed massive lymphoplasmacytic infiltration (>90% were IgG4 + plasma cells), storiform fibrosis, and obliterative phlebitis; thus leading to a diagnosis of IgG4‐RD. We conclude that IgG4‐RD can present as a bilateral ovarian mass along with lymphadenopathy, therefore mimicking ovarian cancer.