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Surgical excision of ovarian endometriomas: Does it truly impair ovarian reserve? Long term anti‐Müllerian hormone (AMH) changes after surgery
Author(s) -
Vignali Michele,
Mabrouk Mohamed,
Ciocca Erika,
Alabiso Giulia,
Barbasetti di Prun Allegra,
Gentilini Davide,
Busacca Mauro
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12830
Subject(s) - medicine , ovarian reserve , anti müllerian hormone , cystectomy , laparoscopy , urology , surgery , gynecology , hormone , pregnancy , infertility , cancer , genetics , bladder cancer , biology
Aim The long‐term effects of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral ovarian endometriomas were evaluated. Methods A total of 22 patients undergoing laparoscopic cystectomy for unilateral endometrioma (n = 10) and bilateral endometriomas (n = 12) were included in the study. Result(s) Serum anti‐Müllerian hormone (AMH) levels significantly decreased from the baseline value (3.98 ± 3.27 ng/mL) one (1.67 ± 1.56 ng/mL), three (2.01 ± 1.70 ng/mL), and six months (2.43 ± 2.39 ng/mL) postoperatively. There was no difference between preoperative and 12 month postoperative AMH levels (4.01 ± 3.39 ng/mL) ( P > 0.05). Patients with bilateral endometriomas had a significantly higher rate of decline in AMH levels 12 months after surgery than patients with monolateral endometriomas ( P = 0.035), but in both groups there was no difference in AMH levels at one and 12 months postoperatively ( P > 0.05). Conclusion(s) AMH levels temporarily decreased after laparoscopic cystectomy for ovarian endometriomas, with complete recovery of preoperative AMH values at 12 months postoperatively. This pattern was equal in patients with bilateral and unilateral ovarian involvement. Patients with bilateral cysts have higher rates of decline of AMH levels compared to patients with unilateral affection.