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First trimester interleukin‐6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients
Author(s) -
Oztas Efser,
Erkenekli Kudret,
Ozler Sibel,
Aktas Aynur,
Buyukkagnıcı Umran,
Uygur Dilek,
Danisman Nuri
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12799
Subject(s) - medicine , subclinical infection , pregnancy , miscarriage , obstetrics , anti thyroid autoantibodies , gestation , gestational age , thyroid , adverse effect , antibody , autoantibody , immunology , genetics , biology
Aim The aim of the present study is to compare pregnancy outcomes among patients with and without thyroid antibodies and/or subclinical hypothyroidism and investigate whether there is an association between first trimester maternal plasma interleukin‐6 (IL‐6) levels and adverse pregnancy outcomes. Methods A case‐control study was carried out including 83 pregnant women (40 thyroid antibody positive and 43 healthy controls). The predictive value of first trimester maternal plasma IL‐6 levels on adverse pregnancy outcomes were investigated. The optimal cut‐off points of IL‐6 for determining maternal and fetal outcomes were evaluated by receiver operating characteristic analyses. Results Compared with the control, median IL‐6 levels were significantly higher in thyroid antibody positive pregnancies (median 1.58 vs 1.63 pg/mL; P = 0.047). IL‐6 levels were found to be significantly higher in women who had suffered a miscarriage ( P = 0.002), preterm delivery ( P < 0.001), intrauterine growth restriction ( P = 0.047), preterm premature rupture of membranes ( P = 0.043) and overall prenatal complications ( P < 0.001). A statistically significant negative correlation between gestational week at birth and IL‐6 levels was also determined among all participants involved in the study (r = ‐0.385, P < 0.001). Conclusion IL‐6 levels are significantly increased in thyroid antibody positive patients and predictive for future adverse outcomes, irrespective of thyroid autoimmunity. Increased first trimester IL‐6 levels independently predict adverse pregnancy outcomes, regardless of subclinical hypothyroidism.