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Incidence and risk factors for recurrent spontaneous preterm birth: A retrospective cohort study in Japan
Author(s) -
Yamashita Michiko,
Hayashi Shusaku,
Endo Masayuki,
Okuno Kentaro,
Fukui On,
Mimura Kazuya,
Tachibana Yosuke,
Ishii Keisuke,
Mitsuda Nobuaki,
Kimura Tadashi
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12786
Subject(s) - medicine , incidence (geometry) , retrospective cohort study , cohort study , pediatrics , cohort , premature birth , obstetrics , gestational age , pregnancy , genetics , physics , biology , optics
Aim The aim of this study was to assess the incidence and risk factors for recurrent spontaneous preterm birth (PTB) in Japan. Material and Methods A retrospective cohort study was conducted at five tertiary perinatal centers in Osaka, Japan from 2008 through 2012. Perinatal data were collected from medical records of women with a singleton gestation and a previous spontaneous PTB. Exclusion criteria were first‐trimester spontaneous abortion, first antenatal visit beyond 14 weeks of gestation, and previous PTB with medical indications, placenta previa, abruptio placenta, multiple pregnancy, fetal anomaly, and antepartum fetal demise. The associations between recurrent spontaneous PTB and perinatal factors were evaluated by logistic regression analysis. Results Of 547 women with a previous spontaneous PTB, 89 (16.3%) suffered a recurrent spontaneous PTB. The risk factors for recurrence included multiple previous spontaneous PTB (adjusted odds ratio [aOR]: 2.26; 95% confidence interval [CI]: 1.19–4.30; P = 0.013), no previous term birth (aOR: 2.08; 95%CI: 1.24–3.49; P = 0.005), and interpregnancy interval < 12 months (aOR: 2.13; 95%CI: 1.17–3.85; P = 0.013). Conclusion Approximately one in six women with a previous spontaneous PTB suffered a recurrent spontaneous PTB. Multiple previous spontaneous PTB, no previous term birth, and short interpregnancy interval were independent risk factors for recurrence.