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Aspartate aminotransferase and free thyroid hormones in vaginal washing fluid as markers for preterm pre‐labor rupture of membranes
Author(s) -
Farag Amr H.,
Elghetany Sherif S.,
Elkashif Mohamed S.
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12730
Subject(s) - medicine , hormone , thyroid hormones , membrane , thyroid , preterm labor , obstetrics , physiology , endocrinology , pregnancy , fetus , biochemistry , biology , genetics
Aim To evaluate the diagnostic value of vaginal fluid aspartate aminotransferase (AST), free triiodothyronine (T 3 ) and free thyroxine (T 4 ) in women with preterm pre‐labor rupture of membranes (PPROM). Methods A case–control study was carried out of 100 women: 50 with PPROM (study group) and 50 age‐, gestational age‐ and weight‐matched women with intact membranes (control group). All women underwent sterile speculum vaginal examination. The vaginal posterior fornix was irrigated and the retrieved fluid was sent for AST, free T 3 and free T 4 assays. Results Median vaginal fluid free T 3 , free T 4 and AST were significantly higher in the PPROM group compared with the control group, with vaginal fluid free T 4 having the largest area under the curve on receiver operating characteristic curve analysis ( P <0.001). Sensitivity, specificity, positive and negative predictive values for free T 3 (cut‐off, 1.06 pg/mL) were 88%, 70%, 74.6% and 85.4%, respectively, while those for free T 4 (cut‐off 0.063 ng/dL) were 86%, 72%, 75.4% and 83.7%, and those for AST (4.5 IU/L) were 56%, 70%, 65.1% and 61.4%, respectively. Vaginal fluid AST had less diagnostic accuracy when compared with either free T 3 or free T 4 . Conclusions Vaginal fluid AST, free T 3 and free T 4 seem to be useful and simple markers in diagnosis of PPROM.