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Effect of S100A6 over‐expression on β‐catenin in endometriosis
Author(s) -
Liu Zequn,
Zhang Xiaoling,
Chen Meihong,
Cao Qing,
Huang Donghua
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12729
Subject(s) - stromal cell , medicine , endometriosis , cancer research , western blot , reverse transcription polymerase chain reaction , catenin , immunohistochemistry , transfection , carcinoma , pathology , gene expression , cell culture , wnt signaling pathway , gene , biology , biochemistry , genetics
Aim S100A6 is over‐expressed in several human tumors, including pancreatic carcinoma, malignant fibrous histiocytoma, breast, colon, and gastric carcinoma, but little is known about the role of S100A6 in endometriosis. The aim of the present study was to investigate the effect of S100A6 over‐expression on β‐catenin in endometrial stromal cells. Methods Endometrial stromal cells were transfected with an hS100A6‐expressing recombinant lentivirus construct. The expression of β‐catenin was assessed using western blot and reverse transcription‐polymerase chain reaction. Results S100A6 over‐expression promoted β‐catenin expression at the RNA and protein levels, in endometrial stromal cells. Conclusions S100A6 induces expression of β‐catenin in endometrial stromal cells.