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Adverse pregnancy outcome in patients with low pregnancy‐associated plasma protein‐ A : The I ndian E xperience
Author(s) -
Gupta Sangeeta,
Goyal Manisha,
Verma Deepti,
Sharma Anjana,
Bharadwaj Namita,
Kabra Madhulika,
Kapoor Seema
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12662
Subject(s) - medicine , pregnancy , pregnancy associated plasma protein a , intrauterine growth restriction , obstetrics , incidence (geometry) , eclampsia , preterm delivery , fetal growth , fetus , adverse effect , first trimester , genetics , physics , optics , biology
Aim The aim of our study was to examine the association of low pregnancy‐associated plasma protein‐ A ( PAPP‐A ) with adverse pregnancy outcome. Material and Methods A total of 1640 consecutive pregnant women between 9 +5 and 13 +6 weeks of pregnancy were recruited. One hundred and thirty women with PAPP‐A levels < 0.4 multiple of median were followed till delivery and the outcome information was obtained for fetal loss, birthweight, growth restriction, preterm birth, reduced liquor and development of pre‐eclampsia. Results During the study period, 130 (7.92%) women had low PAPP‐A and were considered as cases and 200 women with normal PAPP‐A were controls. Intrauterine growth restriction was observed in 28 (21.54%) cases as compared to 10 (5%) controls. Pre‐eclampsia presented in 24 (18.46%) cases and in 18 (9%) controls. Twenty (15.38%) cases had preterm delivery compared to 12 (6%) controls. Fifty‐six (43.08%) cases delivered low‐birthweight babies compared to 22 (11%) controls. Thus, the incidence of intrauterine growth restriction, preterm birth and low birthweight was significantly more in the cases as compared to the control group. Conclusions PAPP‐A is a valuable analyte for predicting risk of adverse pregnancy outcome and women with low serum PAPP‐A levels would benefit from closer surveillance.