Premium
Umbilical cord milking reduces need for red cell transfusions and improves neonatal adaptation in preterm infants: Meta‐analysis
Author(s) -
Dang Dan,
Zhang Chuan,
Shi Shan,
Mu Xin,
Lv Xiaoming,
Wu Hui
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12657
Subject(s) - medicine , necrotizing enterocolitis , incidence (geometry) , umbilical cord , intraventricular hemorrhage , randomized controlled trial , meta analysis , anesthesia , cochrane library , apgar score , blood pressure , pediatrics , surgery , birth weight , gestational age , pregnancy , physics , genetics , biology , optics , anatomy
Aim To assess effects of umbilical cord milking ( UCM ) on early blood pressure stabilization, hemoglobin ( Hb ), as well as incidence of transfusion and complications in preterm infants. Methods This meta‐analysis was conducted by searching the Pubmed, EMBASE and Cochrane Library (until J uly 2014) databases. Any clinical trials, including randomized control trials, comparing UCM to immediate cord clamping ( ICC ) were analyzed. Results Six studies were included in this meta‐analysis. In total, 292 preterm infants were treated with UCM , while 295 received ICC . Compared to ICC , UCM increased initial Hb significantly by 1.84 g/dL (weighted mean difference; 95% CI : 0.91–2.76; P < 0.0001) and decreased the incidence of transfusion with a pooled risk ratio of 0.74 (95% CI : 0.61–0.90; P = 0.002). Incidence of necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH) and mortality were significantly lower with UCM compared with ICC . Apgar score and temperature were not significantly different between the two groups. Conclusions By facilitating the early stabilization of blood pressure, UCM at preterm birth was found to be comparatively safe and associated with lower blood transfusion exposure and lower incidence of IVH, NEC and death.