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Age‐dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in S outh‐ E ast I ran: A preliminary report
Author(s) -
Salimi Saeedeh,
Hajizadeh Azam,
Khodamian Maryam,
Pejman Atefeh,
Fazeli Kimia,
Yaghmaei Minoo
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12625
Subject(s) - medicine , uterine leiomyoma , association (psychology) , leiomyoma , gynecology , mdm2 , oncology , genetics , pathology , gene , philosophy , epistemology , biology
Aim Murine double minute clone 2 ( MDM2 ) is an important regulator of p53 tumor suppressor protein. Because increased MDM2 expression has been observed in different tumors, its polymorphisms are proposed to be associated with accelerated tumor formation. The aim of this study was to examine the association between T309G (rs2279744) and 40‐bp Insertion/deletion (rs3730485) polymorphisms of the MDM2 gene and risk of uterine leiomyoma ( UL ). Methods We analyzed the MDM2 gene polymorphisms of 154 UL patients and 197 healthy controls by polymerase chain reaction ( PCR ) or PCR restriction fragment length polymorphism ( RFLP ) methods. Results The frequency of MDM2 T309G polymorphism genotypes was not different between UL women and controls. Although there was an association between MDM2 40‐bp del/del genotype and UL before and after adjustment for age, the association between Insertion/deletion (Indel) genotype and UL was significant after adjustment for age. Conclusion MDM2 T309G polymorphism was not associated with UL and MDM2 40‐bp Indel polymorphism could be an age‐related risk factor for UL .