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Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29‐year‐old C hinese female: A case report and published work review
Author(s) -
Yi Tianjin,
Wang Ping,
Lin Lin,
Jiang Wei
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12552
Subject(s) - fluorescence in situ hybridization , medicine , ewing's sarcoma , sarcoma , uterus , in situ , in situ hybridization , pathology , peripheral , biology , genetics , gene , chromosome , gene expression , physics , meteorology
Ewing's sarcoma/peripheral primitive neuroectodermal tumors ( ES/ p PNET ) are a group of small round cell sarcomas that show varying degrees of neuroectodermal differentiation characterized by translocation involving the EWS gene. Uterine ES/ p PNET is a rare entity. A 29‐year‐old C hinese female who presented with abdominal swelling and pain was diagnosed with a primary uterine ES/ p PNET on the basis of clinicopathologic, immunohistochemical and fluorescence in situ hybridization ( FISH ) data. She was given a multimodal treatment, including neoadjuvant, 95% cytoreductive, chemotherapy and radiotherapy. The patient is currently alive with persistent disease after 18 months of follow‐up. We emphasized the crucial role of molecular techniques in the differential diagnosis of small round cell tumors in this unusual location. Multimodal therapy may improve the outcomes of patients.

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