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Role of osteoprotegerin gene variants in early‐onset severe pre‐eclampsia
Author(s) -
Yang Yan,
Liu Xijing,
Jia Jin,
Bai Yi,
Dai Li,
Wang Tao,
Zhou Bin,
Zhang Lin,
Zhou Rong
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12533
Subject(s) - medicine , genotype , osteoprotegerin , allele , eclampsia , creatinine , endocrinology , polymorphism (computer science) , allele frequency , blood pressure , gastroenterology , genotype frequency , gene , pregnancy , genetics , biology , receptor , activator (genetics)
Aim The aim of this study was to detect the role of osteoprotegerin ( OPG ) gene variants in early‐onset severe pre‐eclampsia. Material and Methods The associations of 163 A / G (rs3102735) and 950 T / C (rs2073617) polymorphisms of OPG with pre‐eclampsia (60 cases of early‐onset severe pre‐eclampsia and 91 cases of late‐onset pre‐eclampsia), as well as with the clinical manifestations of individuals, were evaluated. Results Data showed lower frequencies of TC and TC + CC genotypes and C allele of 950 T / C in the early‐onset group than those of the control and late‐onset groups ( P = 0.003; P = 0.002; P = 0.005; P = 0.031; P = 0.021; P = 0.022). However, no significant differences were found in genotype and allele frequencies between the late‐onset and control groups. Moreover, no significant differences were observed in the genotype and allele frequencies of 163 A / G polymorphism among the three groups. In the early‐onset group, 950 T / C TC + CC genotype carriers exhibited significantly lower systolic blood pressure ([147.25 ± 11.89] mmHg) and 24‐h urine protein ([2.46 ± 0.92] g) than the TT carriers ([165.88 ± 20.39] mmHg, [3.64 ± 0.81] g) ( P = 0.003; P = 0.001, respectively). Serum creatinine was significantly higher in women with the 163 A / G AG + GG genotypes ([82.31 ± 11.66] μmol/L) than in those with the AA genotype ([71.90 ± 16.85] μmol/L) ( P = 0.003). Conclusion This study implicates that OPG gene variants may be associated with early‐onset severe pre‐eclampsia.