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Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus
Author(s) -
Gözükara Yavuz M.,
Aytan Hakan,
Ertunc Devrim,
Tok Ekrem C.,
Demirtürk Fazli,
Şahin Şemsettin,
Aytan Pelin
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12525
Subject(s) - medicine , gestational diabetes , testosterone (patch) , obstetrics , body mass index , pregnancy , gynecology , prospective cohort study , gestation , diabetes mellitus , dehydroepiandrosterone sulfate , endocrinology , androgen , hormone , genetics , biology
Aim To assess the role of first trimester maternal testosterone and dehydroepiandrosterone sulfate ( DHEA‐S ) levels in prediction of development of gestational diabetes mellitus ( GDM ). Methods Four hundred and fifty pregnant women were included in this prospective cohort study. All pregnant women with a singleton pregnancy who were not diabetic, had no family history of diabetes, had no history of previous GDM , were of white race and non‐smokers were enrolled. Total testosterone and DHEA‐S were measured at 11–14 weeks of gestation. The patients were called for routine pregnancy visits and followed accordingly. Forty‐two patients did not come to their visits and were excluded. During gestational weeks 24–28, the remaining 408 patients were screened for GDM . The total testosterone and DHEA‐S levels were compared between patients with and without GDM . Regression and receiver–operator curve analysis were performed. Results GDM developed in 22 women (5.7%). Compared with women without GDM , first trimester total testosterone levels were higher among women in whom GDM subsequently developed. The DHEA‐S level did not differ. Age, total testosterone and body mass index were found to be independent predictors of GDM development. A total testosterone value of 0.45 ng/mL was found to predict development of GDM with a sensitivity of 63.6% and a specificity of 62.7%. Conclusion First trimester total testosterone has a low testing power for GDM screening with low sensitivity and specificity values and cannot be used as a marker alone. It may have a role in combination with other markers.