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Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility‐sparing management
Author(s) -
Morimoto Atsushi,
Tsubamoto Hiroshi,
Inoue Kayo,
Ikeda Yuuki,
Hirota Seiichi
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12506
Subject(s) - medicine , endometrial stromal sarcoma , stromal cell , sarcoma , fertility , uterus , gynecology , oncology , pathology , population , environmental health
Several cases of the uterus being preserved after diagnosis of endometrial stromal sarcoma ( ESS ) have been reported. Most of these patients were alive and did not experience relapse, but this might have reflected the short follow‐up period, given the indolent recurrence of ESS . We report the first fatal case of ESS 10 years after fertility‐sparing management. A specimen obtained from the last operation showed loss of estrogen receptor status and expression of c‐kit without c‐kit or PDGFR ‐α gene mutations.