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Assessment of women who applied for the uterine transplant project as potential candidates for uterus transplantation
Author(s) -
Erman Akar Munire,
Ozekinci Murat,
Alper Ozgul,
Demir Durkadin,
Cevikol Can,
Meric Bilekdemir Asli,
Daloglu Aylin,
Ongut Gozde,
Senol Yesim,
Ozdem Sebahat,
Uzun Gulbahar,
Luleci Guven,
Suleymanlar Gultekin
Publication year - 2015
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12486
Subject(s) - medicine , gynecology , amenorrhea , hysterectomy , infertility , complete androgen insensitivity syndrome , etiology , ovarian reserve , antral follicle , obstetrics , hormone , pregnancy , surgery , genetics , androgen receptor , prostate cancer , cancer , biology
Abstract Aim To review the medical charts of women who applied for the uterine transplant project from J une 2008 to J une 2011 in our hospital retrospectively (18–40 years). Methods The data for 144 women were retrieved, and information was collected on the etiology of uterine factor infertility( UFI ); ovarian reserve tests; and accompanying anatomic, infectious, genetic and endocrinological problems. Results There were 119 patients with primary amenorrhea and uterovaginal agenesis and 25 patients with a history of hysterectomy. The complete M üllerian agenesis patients formed the largest group of the UFI patients with better anti‐Müllerian hormone levels and antral follicle count. Anatomical anomalies such as a solitary pelvic kidney may accompany M ayer– R okitansky– K uster– H auser syndrome ( MRKH ) and impede surgery. The mean ages in MRKH , hysterectomy and complete androgen insensitivity syndrome ( CAIS ) cases were 24.7, 35.0 and 34.4 years, respectively. The karyotype analysis showed 46 XX ( MRKH ) in 109 patients and 46 XY ( CAIS ) in 10 of the primary amenorrhea patients. Conclusion Hysterectomy may deteriorate ovarian blood flow and decrease ovarian reserve. Fertility preservation may be considered in young woman undergoing hysterectomy.