Premium
Ovarian steroid cell tumor, not otherwise specified, producing testosterone
Author(s) -
Mizoguchi Mika,
Minami Sawako,
Yamamoto Madoka,
Tanizaki Yuko,
Kobayashi Aya,
Ino Kazuhiko
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12467
Subject(s) - virilization , medicine , testosterone (patch) , leydig cell tumor , ovarian tumor , ovary , steroid , dehydroepiandrosterone sulfate , endocrinology , pathology , androgen , ovarian cancer , leydig cell , hormone , cancer , luteinizing hormone
Steroid cell tumor, not otherwise specified, is a rare type of ovarian sex cord‐stromal tumor with malignant potential. Some of these tumors produce testosterone. We describe a case of steroid cell tumor of the ovary associated with virilization. A 23‐year‐old nulliparous woman was found to have an ovarian tumor when she visited her primary doctor for virilization and oligomenorrhea. Magnetic resonance imaging revealed a solid left ovarian tumor 40 mm in size. Her laboratory data revealed elevated testosterone with normal levels of gonadotropins, estradiol, dehydroepiandrosterone sulfate and cortisol. She underwent left adnexectomy. On histopathologic and immunohistochemical analyses, the tumor was diagnosed as steroid cell tumor, not otherwise specified, without malignant behavior. After removal of the tumor, serum testosterone level decreased, and there have been no signs of recurrence.