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Efficacy of kidney‐tonifying traditional C hinese medicine prescriptions in hypoplastic uterus treatment: A systematic review and meta‐analysis
Author(s) -
Chen Xichuang,
Hong Yuan,
Zheng Panpan,
Qin Yaping,
Zhang Xiaoyan,
Feng Jinhua,
Ye Jianlin,
Song Huizhu,
You Xiaohong
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12451
Subject(s) - medicine , randomized controlled trial , confidence interval , meta analysis , adverse effect , strictly standardized mean difference
Aim To review and evaluate the efficacy of kidney‐tonifying traditional C hinese medicine prescriptions ( KT ‐ TCMP ) in hypoplastic uterus ( HU ) treatment. Methods We searched MEDLINE , the C ochrane L ibrary, CNKI ( C hina N ational K nowledge I nfrastructure), WANFANG and VIP databases until 14 D ecember 2013 independently with two investigators. Randomized controlled trials ( RCT ) involving KT ‐ TCMP as a combined or monotherapy in the treatment of HU were reviewed and analyzed. Meta‐analysis was performed by R eview M anager (version 5.2). Results Nine RCT of 1745 patients were eligible for this review and meta‐analysis, of which eight RCT described the primary outcome of clinical efficacy and three RCT drew the secondary outcome of uterine size. Meta‐analyzed ‘recovery’ clinical efficacy of KT ‐ TCMP in seven RCT was conducted which considered diethylstilbestrol therapy alone as control, as well as three RCT that meta‐analyzed the effect of KT ‐ TCMP on uterine diameter enlargement. As a result, KT ‐ TCMP therapy had a significantly improved difference in increasing ‘recovery’ clinical efficacy (risk ratio, 2.34; 95% confidence interval [ CI ], 1.90–2.89) and enlarging the uterine diameter (standardized mean difference, 1.62; 95% CI , 1.39–1.84). One study reported adverse reactions as an important outcome and found it was safe during KT ‐ TCMP therapy. Conclusion The therapy of applying KT ‐ TCMP as a combined or monotherapy in the treatment of HU may be more efficacious. However, these RCT were of moderate methodological quality and small sample size; thus, the results should be confirmed with more rigorously controlled further studies.