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Prediction of histological types of endometrial cancer by endometrial cytology
Author(s) -
Okadome Masao,
Saito Toshiaki,
Nishiyama Naoko,
Ariyoshi Kazuya,
Shimamoto Kumi,
Shimada Takako,
Kodama Keisuke,
Imamura Shogo,
Nishiyama Kenichi,
Taguchi Kenichi
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12436
Subject(s) - medicine , cytology , endometrial cancer , biopsy , serous fluid , histology , endometrial biopsy , gynecology , adenocarcinoma , carcinoma , radiology , cancer , pathology
Abstract Aim Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low‐ and high‐risk histology in women with endometrial cancer ( EC ). This single‐institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low‐risk and high‐risk histology of EC . Methods Between J anuary 2006 and M arch 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in N ational K yushu C ancer C enter. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single‐use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest. Results For type 2 EC , which includes grade 3 endometrioid adenocarcinoma and non‐endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC , and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC , 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology ( P = 0.002). Conclusion Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC .