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Two cases of recurrent abortion in which isodicentric chromosome 15 was observed in the husbands
Author(s) -
aka Taro,
Ooki Izumi,
Enomoto Takayuki,
Takakuwa Koichi
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12401
Subject(s) - medicine , abortion , anticardiolipin antibodies , obstetrics , gynecology , aspirin , pregnancy , antibody , immunology , genetics , biology
We report two cases of women positive for anticardiolipin antibodies who experienced recurrent abortion whose husbands had isodicentric chromosome 15 aberrations who eventually had successful pregnancies. Two women were referred to our hospital due to their medical history of recurrent abortion. Both were diagnosed as being positive for anticardiolipin antibodies and their husbands with isodicentric chromosome 15. After both patients were treated with a Japanese herbal medicine ( Sairei‐to ) and low‐dose aspirin for the positive anticardiolipin antibodies, they delivered appropriate‐for‐date infants at term gestation. Although both husbands were revealed to have isodicentric chromosome 15, and coincidentally both wives were positive for anticardiolipin antibodies, their next pregnancies continued uneventfully as a result of the treatment.