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Clinical analysis of 65 cases of hyperemesis gravidarum with gestational transient thyrotoxicosis
Author(s) -
Sun Shuiya,
Qiu Xia,
Zhou Jiaqiang
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12372
Subject(s) - medicine , hyperemesis gravidarum , thyroid function , subclinical infection , endocrinology , pregnancy , thyroid , thyroid function tests , thyroid peroxidase , gestational age , gestation , gastroenterology , vomiting , biology , genetics
Aim We investigated thyroid function and the impact of gestational transient thyrotoxicosis ( GTT ) on pregnancy outcome in patients with hyperemesis gravidarum ( HG ; n  = 143) who were hospitalized for rehydration. Methods Serum thyroid‐stimulating hormone ( TSH ), free T 3 ( FT 3), free T 4 ( FT 4), thyroid globulin antibody ( TgAb ), thyroid peroxidase antibody ( TPOAb ) and hCG were measured after admission. Results The total prevalence of thyrotoxicosis in HG was 48.3%; GTT was the main form (45.5%). The total incidence of GTT increased significantly if serum hCG was more than 80 000 IU/L, subclinical GTT if serum hCG was 80 000–140 000 IU/L and clinical GTT if serum hCG was more than 180 000 IU/L. GTT did not require antithyroid therapy. The course of TSH , FT 3 and FT 4 were followed in 34 cases of GTT ; thyroid function normalized by the second trimester. Of 65 patients with GTT , two underwent abortions due to unplanned pregnancies, two delivered prematurely and two infants had macrosomia. There were no other complications. All newborns ( n  = 63) of mothers with GTT had normal TSH levels. Conclusion GTT is common in HG . The severity of GTT is related to serum hCG levels. In patients with HG and GTT , thyroid function normalized by the second trimester without antithyroid treatment. GTT did not affect pregnancy outcomes.

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