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Risk of cerebral palsy associated with neonatal encephalopathy in macrosomic neonates
Author(s) -
Yamada Takahiro,
Akaishi Rina,
Yamada Takashi,
Morikawa Mamoru,
Kaneuchi Masanori,
Minakami Hisanori
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12367
Subject(s) - medicine , cerebral palsy , pediatrics , gestational age , confidence interval , birth weight , encephalopathy , neonatal encephalopathy , obstetrics , pregnancy , physical therapy , biology , genetics
Abstract Aim To determine whether macrosomic infants with a birthweight of 4.0 kg or more have increased risk of cerebral palsy associated with neonatal encephalopathy ( E nc‐ CP ). Methods A retrospective review of 132 singleton infants with E nc‐ CP fulfilling all of the following criteria: born at gestational week ( GW ) 37 or more ( n = 126) or weighing 2.5 kg or more at birth ( n = 116) in or after J anuary 2009 in J apan; no identifiable causes of cerebral palsy other than antenatal or intrapartum hypoxia; and exhibition of neonatal encephalopathy. National statistics of J apan were used to determine the numbers of infants according to birthweight categories. Results Of the 116 infants with a birthweight of 2.5 kg or more, 46 (39.7%), 49 (42.2%), 17 (14.7%) and four (3.4%) infants had birthweights of 2.5–2.99, 3.0–3.49, 3.5–3.99 and 4.0 kg or more, respectively. Corresponding figures among Japanese infants born in 2009–2011 were 42.8%, 45.4%, 10.9% and 0.90%, respectively. Infants with a birthweight of 4.0 kg or more had a relative risk (95% confidence interval) of E nc‐ CP of 3.89 (1.52–9.95) compared to those with a birthweight of 2.5–2.99 kg. Conclusion Japanese infants with a birthweight of 4.0 kg or more have increased risk of E nc‐ CP .