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Management of squamous cell vulvar cancer: A review
Author(s) -
Deppe Gunter,
Mert Ismail,
Winer Ira S.
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12352
Subject(s) - medicine , vulvar cancer , vulva , malignancy , biopsy , stage (stratigraphy) , sentinel lymph node , vulvar neoplasm , oncology , chemotherapy , cancer , radiology , surgery , breast cancer , paleontology , biology
Squamous cell vulvar cancer is a rare gynecologic malignancy. Standard treatment for early stage disease consists of wide radical excision of the primary tumor with inguinal–femoral lymphadenectomy or sentinel lymph node mapping/biopsy. Because of the general paucity of patients with advanced vulvar cancer, there is no standard therapy for advanced disease and therefore treatment should be individualized. Intergroup trials are needed to clarify the value of chemoradiation, neoadjuvant chemotherapy and targeted therapy in patients with advanced squamous cell cancer of the vulva to identify modalities with the best therapeutic index and lowest morbidity.