Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre‐eclampsia

Aim Pre‐eclampsia ( PE ) is a complex disorder of pregnancy with unknown etiology. FAS ‐mediated apoptosis is assumed to prevent the development of PE ; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand   A ‐670 G (rs1800682) and FAS Ligand   C ‐844 T (rs763110) gene polymorphisms with PE in southeast I ran. Methods One hundred and twenty‐seven unrelated women with PE and 139 healthy control subjects were genotyped for the FAS A ‐670 G and FAS Ligand   C ‐844 T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method. Results The AA , AG and GG genotype frequency of the FAS A ‐670 G polymorphism were 21.3%, 53.5% and 25.2% in pre‐eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different ( P  = 0.0001). The risk of PE was 2.7‐ and 4.7‐fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS Ligand   C ‐844 T gene polymorphism was higher in the PE group, the differences were not significant. Conclusion FAS A‐670G polymorphism is associated with a higher risk for PE . There was no association between FAS Ligand   C ‐844 T polymorphism and PE .