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Effectiveness of estrogen in the prevention of intrauterine adhesions after hysteroscopic septal resection: A prospective, randomized study
Author(s) -
Roy Kallol Kumar,
Negi Neha,
Subbaiah Murali,
Kumar Sunesh,
Sharma Jai Bhagwan,
Singh Neeta
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12297
Subject(s) - medicine , hysteroscopy , estrogen , randomized controlled trial , prospective cohort study , resection , gynecology , surgery
Aim The aim of this prospective randomized study was to evaluate the efficacy of estrogen in preventing intrauterine adhesions following hysteroscopic septal resection and to investigate its effect on reproductive outcome. Materials and Methods After hysteroscopic septal resection, 90 women received either estrogen or placebo ( n = 45 per group) for 30 days. A second‐look hysteroscopy was performed after 2 months. All pregnancies occurring during the study period were recorded. Results Adhesions developed in three of 43 (6.9%) patients in the control group compared to none in the estrogen group. This difference was not statistically significant ( P = 0.24). Regarding reproductive outcome, the differences between the two groups were also not significant. Conclusion Estrogen treatment was not found to prevent intrauterine adhesions or improve reproductive outcome after hysteroscopic septal resection.