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Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: Case report and review of published works
Author(s) -
Asada Kayo,
Kawana Kei,
Teshima Shinichi,
Saito Ako,
Kawabata Masakiyo,
Fujii Tomoyuki
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12235
Subject(s) - medicine , chemotherapy , ovarian cancer , stage (stratigraphy) , oncology , adjuvant chemotherapy , cancer , neuroendocrine carcinoma , carcinoma , breast cancer , paleontology , biology
Large cell neuroendocrine carcinoma ( LCNEC ) is well‐reported to result in unfavorable prognoses in many organ cancers while being rarely reported in gynecologic cancer, especially ovarian and endometrial cancers. Here we report a case of ovarian cancer with LCNEC which spread to distant organs within 1 year of primary surgery despite the fact that the post‐surgical stage was Ia. The case received platinum‐based chemotherapy as an adjuvant therapy after her curative surgery. However, LCNEC in the case was resistant to the chemotherapy. In our review of published works, ovarian cancer cases with LCNEC show poor prognoses regardless of adjuvant chemotherapy following complete resection. Median overall survival was 10 months in stage I cases. Development of chemotherapy sensitive for LCNEC is needed.