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Evaluation of the efficacy of F ructus agni casti in women with severe primary dysmenorrhea: A prospective comparative D oppler study
Author(s) -
Aksoy Ayse Nur,
Gözükara Ilay,
Kabil Kucur Suna
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12221
Subject(s) - medicine , drospirenone , menstrual cycle , visual analogue scale , uterine artery , gynecology , pulsatility index , prospective cohort study , hormone , surgery , pregnancy , fetus , gestation , biology , genetics
Abstract Aim The aim of this case–control study was to compare the efficacy of ethinyl estradiol/drospirenone and F ructus agni casti in women with severe primary dysmenorrhea measuring uterine artery blood flow via D oppler ultrasonography. Methods A total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) were included in this study. Thirty patients were treated with ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 were treated with F ructus agni casti (group 2) during three menstrual cycles. Before and at the end of third month of therapy visual analog scale ( VAS ) scores, pulsatility index ( PI ), resistance index ( RI ) of uterine artery were recorded before and after receiving therapy on the first day of the menstrual cycle. Results Mean PI and RI values in patients with severe primary dysmenorrhea were significantly higher than in the control groups on the first day of the menstrual cycle ( P < 0.0001). Mean PI and RI values were significantly lower after the treatment in both groups compared to before values ( P < 0.001 for both). After using the drugs for three menstrual cycles, VAS scores were significantly dropped in both groups compared to before treatment values ( P < 0.0001 for both); however, there were no significant differences in terms of D oppler findings between group 1 and 2. Conclusion The effectiveness of F ructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea.