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Paraneoplastic cerebellar degeneration caused by ovarian clear‐cell carcinoma
Author(s) -
Negishi Y.,
Sakai K.,
Noguchi Y.,
Iwasaki N.,
Kawai N.
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12212
Subject(s) - paraneoplastic cerebellar degeneration , medicine , malignancy , cerebellar degeneration , pathology , ovarian cancer , dysarthria , vertigo , cerebellum , ovarian carcinoma , cancer , surgery , radiology , immunology , antibody , autoantibody
Paraneoplastic cerebellar degeneration is a paraneoplastic neurological syndrome caused by the remote effect of certain systemic cancers and is characterized by subacute cerebellar symptoms. A 62‐year‐old woman suffering from unidentified cerebellar symptoms was admitted to our hospital. Paraneoplastic cerebellar degeneration was suspected and ovarian cancer was detected after the systemic examination for malignancy. The symptoms of vertigo and dysarthria were improved a little after surgical operation and treatments of γ‐globulin, steroid pulse and tacrolimus hydrate. The cerebellar symptoms of paraneoplastic cerebellar degeneration are often evident prior to detection of malignancy. It is important to perform systemic examination for malignancy in case of unidentified cerebellar symptoms.