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Comparison between placental gene expression of 11β‐hydroxysteroid dehydrogenases and infantile growth at 10 months of age
Author(s) -
MuramatsuKato Keiko,
Itoh Hiroaki,
KobayashiKohmura Yukiko,
Murakami Hirotake,
Uchida Toshiyuki,
Suzuki Kazunao,
Sugihara Kazuhiro,
Kanayama Naohiro,
Tsuchiya Kenji J.,
Takei Nori
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12200
Subject(s) - umbilical cord , placenta , medicine , endocrinology , gene expression , cord blood , andrology , fetus , gene , pregnancy , biology , immunology , genetics
Aim The local expression of two isoenzymes of 11β‐hydroxysteroid dehydrogenase, type 1 (11β HSD ‐1) and type 2 (11β HSD ‐2), regulates the access of glucocorticoid hormones to their target cells. Reports on the association between the placental expression of 11β HSD and infantile growth are limited. The aim of the present study was to investigate if the placental gene expression of 11β HSD affects infantile growth at 10 months of age. Methods Placentas and umbilical venous cord blood were obtained from 42 singleton cases of cesarean deliveries between 31 and 40 weeks of gestation at H amamatsu U niversity H ospital between M arch 2009 and J une 2010. The gene expression of both 11β HSD ‐1 and 11β HSD ‐2 was measured by quantitative reverse transcription polymerase chain reaction. Adiponectin and leptin levels in umbilical cord blood were measured using enzyme‐linked immunoassay. Results 11β HSD ‐1 and 11β HSD ‐2 gene expression in human placentas did not correlate with bodyweight or the ponderal index ( PI ) at 10 months of age, whereas the gene expression of 11β HSD ‐1, but not 11β HSD ‐2, correlated with birthweight as well as PI at birth. Adiponectin levels in umbilical cord blood significantly correlated with the placental gene expression of 11β HSD ‐1 as well as bodyweight and PI at 10 months of age, although no direct correlation was observed between them. Conclusion No direct correlation was observed between the placental gene expression of 11β HSD and infantile growth at 10 months of age. However, the placental gene expression of 11β HSD ‐1 may be indirectly connected with infantile growth via adiponectin‐associated metabolic regulation represented by adiponectin levels in umbilical cord blood.