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Lack of association between LIPC ‐514 C/T polymorphism of hepatic lipase and endometriosis in I ranian women
Author(s) -
Sahmani Mehdi,
Ghaleh Talaat Dabbaghi,
Darabi Maryam,
Darabi Masoud,
Rashvand Zahra,
Najafipour Reza
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12191
Subject(s) - endometriosis , hepatic lipase , medicine , polymorphism (computer science) , gene polymorphism , gastroenterology , gene , genotype , cholesterol , genetics , triglyceride , biology
Aim Patients with endometriosis may suffer from dyslipidemia. Hepatic lipase ( HL ) is involved in the metabolism of lipoproteins and has an important role in reverse cholesterol transport. The aim of this study was to investigate the association between the LIPC ‐514 C / T polymorphism in the HL gene and the risk of endometriosis in a group of Iranian women. Methods Ninety‐seven patients with endometriosis and 107 women who were negative for endometriosis after diagnostic laparoscopy, as control group, were enrolled in this cross‐sectional study. Samples were analyzed for polymorphism of the HL gene using polymerase chain reaction restriction fragment length polymorphism. Results Multivariate analysis was used to examine the association between the risk of endometriosis and LIPC ‐514 C/T polymorphism. There was no statistically significant difference in the frequency of the LIPC ‐514 C/T polymorphism between patients and the controls (60.7% CC , 34.6% CT , 4.7% TT versus 68.4%, 27.4%, 4.2%, respectively, P = 0.52). Conclusion The present study suggested that the LIPC ‐514 C/T polymorphism of the HL gene has no significant association with the risk of endometriosis in the studied Iranian women.