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Endodermal sinus tumor of vagina posing a diagnostic challenge and managed by chemotherapy and novel posterior sagittal surgical approach: Lessons learned
Author(s) -
Goyal Surbhi,
Puri Archana,
Mishra Kiran,
Aggarwal Satish Kumar,
Kumar Manisha,
Sonaker Pitamber
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12182
Subject(s) - medicine , vagina , endodermal sinus tumor , rhabdomyosarcoma , malignancy , vaginal bleeding , embryonal rhabdomyosarcoma , germ cell tumors , radiological weapon , gynecology , surgery , chemotherapy , radiology , sarcoma , pathology , pregnancy , biology , genetics
Vaginal germ cell tumor ( GCT ) is a rare gynecological malignancy with no more than 100 reported cases in the international medical literature. It is an unusual, but an important, cause of premenarchal vaginal bleeding in a child. This article describes a 2‐year‐old child with vaginal GCT , initially misdiagnosed as rhabdomyosarcoma (on imprint smear cytology) and then as clear cell adenocarcinoma. The authors highlight the salient differentiating clinical, radiological and histological features to prevent misdiagnosis in future. The report emphasizes the need for increased awareness and screening for vaginal GCT by estimation of serum α‐fetoprotein levels, in all patients with premenarchal vaginal bleeds, to prevent inadvertent operative interventions.