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18 F ‐Fluorodeoxyglucose uptake and clinicopathological features of recurrent or metastatic endometrial stromal sarcoma
Author(s) -
Inoue Kayo,
Tsubamoto Hiroshi,
Kawata Shuji,
Hao Hiroyuki,
Ikeda Yuki,
Oku Naohiko,
Hirota Seiichi
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12180
Subject(s) - positron emission tomography , medicine , standardized uptake value , positron emission , endometrial stromal sarcoma , fluorodeoxyglucose , estrogen receptor , progesterone receptor , nuclear medicine , radiology , sarcoma , pathology , breast cancer , cancer
Aim Maximum standardized uptake value on 18 F ‐fluorodeoxyglucose positron emission tomography was evaluated as a predictive surrogate marker in developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma. Methods Clinical information was obtained from records of patients with recurrent or metastatic endometrial stromal sarcoma who underwent surgery or biopsy following 18 F ‐fluorodeoxyglucose positron emission tomography. Pathological features – including estrogen receptor, progesterone receptor and K i‐67 expression – were immunohistochemically evaluated. We classified lesions as ‘positron emission tomography positive’ if the maximum standardized uptake value was 3.0 or higher. Clinicopathological features were compared between patients with positive and negative positron emission tomography findings by using the χ 2 ‐test. Results Among eight recurrent and one metastatic endometrial stromal sarcoma patients, four (44%) had positron emission tomography‐positive findings. Two positron emission tomography‐positive patients were estrogen receptor negative and the five positron emission tomography‐negative patients were estrogen receptor positive ( P = 0.073). The K i‐67 index was 10% or higher in the four positron emission tomography‐positive patients, but less than 5% in the five positron emission tomography‐negative patients ( P = 0.003). Three patients with positron emission tomography‐positive tumors received more aggressive treatment (e.g. cytotoxic chemotherapy and additional surgery) than did those with positron emission tomography‐negative tumors. One patient who died of disease had positron emission tomography‐positive tumors, was negative for estrogen and progesterone receptors, and had a 20% K i‐67 index. Conclusion 18 F ‐Fluorodeoxyglucose uptake was associated with tumor biology of recurrent or metastatic endometrial stromal sarcoma. 18 F ‐fluorodeoxyglucose‐positron emission tomography was useful for developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma.