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Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component
Author(s) -
Takamatsu Shiro,
Matsumura Noriomi,
Baba Tsukasa,
Mandai Masaki,
Mikami Yoshiki,
Konishi Ikuo
Publication year - 2014
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12136
Subject(s) - medicine , carcinosarcoma , carboplatin , hysterectomy , malignancy , lymphadenectomy , pathology , carcinoma , lymph node , chemotherapy , cisplatin
Humoral hypercalcemia of malignancy ( HHM ) is a paraneoplastic syndrome primarily caused by a tumor‐producing parathyroid hormone‐related protein ( PTH ‐ rP ). We describe the first reported case of a uterine carcinosarcoma causing HHM . A 70‐year‐old patient was transferred to our hospital for a uterine tumor accompanied by impaired consciousness. The laboratory tests indicated anemia, malnutrition, elevated serum calcium and elevated PTH ‐ rP . Emergency surgery, including abdominal hysterectomy and bilateral salpingo‐oophorectomy, was performed due to uncontrollable uterine bleeding. The pathological diagnosis was carcinosarcoma consisting of pure squamous cell carcinoma in its epithelial component. Postoperatively, chemotherapy with paclitaxel and carboplatin was performed. The patient had recurrent tumors at the para‐aortic lymph nodes 11 months after the initial surgery and underwent a pelvic and para‐aortic lymphadenectomy, which removed all of the recurrent tumors.