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Obstetrical complications associated with first‐trimester screening markers in twin pregnancies
Author(s) -
Iskender Cantekin,
Tarım Ebru,
Çok Tayfun,
Yalcınkaya Cem,
Kalaycı Hakan,
Yanık Filiz Bilgin
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12091
Subject(s) - medicine , obstetrics , twin pregnancy , gestation , intrauterine growth restriction , pregnancy , percentile , fetus , gestational age , small for gestational age , pregnancy associated plasma protein a , first trimester , gynecology , statistics , mathematics , biology , genetics
Aim The aim of this retrospective study was to investigate the relation between perinatal complications in twin pregnancies and the combination of first‐trimester maternal serum pregnancy‐associated plasma protein‐ A ( PAPP ‐ A ) and free beta‐human chorionic gonadotrophin (β‐ hCG ) levels. Material and Methods The study was conducted at the P erinatology D epartment of B askent U niversity between J anuary 2005 and D ecember 2011. In total, 104 patients with twin pregnancies were recruited. The association of first‐trimester maternal serum‐screening markers with perinatal complications was investigated for small‐for‐gestational‐age ( SGA ) fetuses or intrauterine growth restriction ( IUGR ), preterm delivery (before 34 weeks of gestation), pregnancy‐induced hypertension ( PIH ), and growth discordance between fetuses. Results Low serum PAPP ‐ A (below 10th percentile) levels were not correlated with preterm labor, PIH , or IUGR in twin gestations. Elevated free β‐ hCG levels (>90th percentile) were linked to increased rates of PIH and small‐for‐gestational‐age fetuses or IUGR . Conclusion Elevated first‐trimester free β‐ hCG was related to adverse pregnancy outcomes in twin pregnancies, whereas low PAPP ‐ A levels were not linked to adverse pregnancy outcomes.