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Effect of vitamin C on the growth of experimentally induced endometriotic cysts
Author(s) -
Durak Yildirim,
Kokcu Arif,
Kefeli Mehmet,
Bildircin Devran,
Çelik Handan,
Alper Tayfun
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.12050
Subject(s) - medicine , stromal cell , laparotomy , cyst , distilled water , vitamin d and neurology , vitamin , andrology , endocrinology , pathology , surgery , chemistry , chromatography
Aim The aim of this study was to investigate the effect of vitamin C on the growth of experimental endometriotic cysts. Material and Methods The endometrium of the uterine horn wall (diameter, 4 mm) was implanted onto the inner surface of the anterior abdominal wall of 40 W istar albino adult female rats, by laparotomy. The day after the implantation, the rats were randomly assigned into four groups (control group and experimental groups [ V 1, V 2, and V 3]) comprising 10 rats each. For 6 weeks, the control group ( G roup C ) received 1 mL distilled water, whereas the experimental groups ( G roups V 1, V 2, and V 3) received 0.5 mg, 1.25 mg, and 2.5 mg of vitamin C in 1 mL of distilled water, respectively. The doses were given via oral gavage once per day. At the end of the administration, a second laparotomy was performed and endometriotic cyst volumes and weights of rats among the groups were compared. In addition, the stromal and glandular tissue and the natural killer cell contents of the cysts were compared among the groups. Results The cyst volume in G roup V 3 and the cyst weights in G roups V 2 and V 3 were significantly lower than those in G roup C . The natural killer cell content in G roups V 1, V 2, and V 3 was significantly lower than that in G roup C . Stromal and glandular tissue contents of the groups were not significantly different. Conclusions The dose‐dependent vitamin C supplementation significantly reduced the volumes and weights of the endometriotic cysts.