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Myocardial Cytosolic Calcium Accumulation During Ischemia/Reperfusion: The Effects of Aging and Cardioplegia
Author(s) -
McCully James D.,
Tsukube Takuro,
Ataka Keiji,
Krukenkamp Irvin B.,
Feinberg Harold,
Levitsky Sidney
Publication year - 1994
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.1994.9.3s.449
Subject(s) - medicine , calcium , magnesium , cytosol , ischemia , potassium , cardiology , calcium metabolism , anesthesia , enzyme , biochemistry , chemistry , organic chemistry
Cytosolic calcium in the myocardium is rapidly accumulated during ischemla and has been correlated with the attenuation of functional recovery in the myocardium. The aged myocardium is more sensitive to ischemia and accumulates significantly more cytosolic calcium than either the newborn or the mature myocardium. Modification of the age‐related propensity to increased cytosolic calcium accumulation may be achieved through the use of magnesium or potassium/magnesium cardioplegia. Improved postischemic ventricular function obtained with magnesium or potassium/magnesium cardioplegia may have important implications in the reduction of myocardial morbidity and mortality.