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The Effect of L‐Carnitine on Force Development of the Latissimus Dorsi Muscle in Dogs
Author(s) -
Dubelaar Marie-Louise,
Lucas Carolien M.B.H.,
Hülsmann Willem C.
Publication year - 1991
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.1991.6.1s.270
Subject(s) - carnitine , medicine , latissimus dorsi muscle , stimulation , compartment (ship) , anatomy , endocrinology , oceanography , geology
Using the latissimus dorsi (LD) muscle of the dog in situ, the effect of carnitine was tested for increase of force in the first period after stimulation. Carnitine administration resulted in an increase of force of 31 ± 6% (mean ± SEM). It is hypothesized that, during muscle stimulation, a relative carnitine deficiency occurs in cells of the vascular compartment. The previously observed lesser effect of carnitine in the trained muscle than in the untrained muscle is in line with this hypothesis, since the number of capillaries is known to increase by training. Also in agreement with this hypothesis is the observation that carnitine increased flow during exercise of the muscle.