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The Role of Passive Stretch and Repetitive Electrical Stimulation in Preventing Skeletal Muscle Atrophy While Reprogramming Gene Expression to Improve Fatigue Resistance
Author(s) -
Goldspink David F.,
Easton Juliet,
Winterburn Susan K.,
Williams Pamela E.,
Goldspink Geoffrey E.
Publication year - 1991
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.1991.6.1s.218
Subject(s) - stimulation , medicine , anabolism , atrophy , muscle atrophy , functional electrical stimulation , reprogramming , skeletal muscle , muscle fatigue , myocyte , microbiology and biotechnology , anatomy , physical medicine and rehabilitation , gene , electromyography , biology , biochemistry
The effects of mechanical stimuli on preserving muscle mass while transforming them into slow, fatigue resistant muscles have been studied in the rabbit. When combined, stretching and electrical stimulation (10 Hz) Induce rapid and marked growth of muscles. This procedure also more rapidly activates the transformation process(es) than when either stretching or electrical stimulation (10 Hz) are used alone. Stretch by itseif is also anabolic causing useful lengthening of muscles and preventing collagen accumuiation. In contrast, muscle inactivity leads to rapid atrophy, fiber shortening and reduced muscle compliance. We believe these findings have important implications to cardiomyoplasty.