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Skeletal Muscle Ventricles: A Promising Treatment Option for Heart Failure
Author(s) -
Pochettino Alberto,
Anderson David R.,
Hammond Robert L.,
Spanta Ali D.,
Hohenhaus Elke,
Niinami Hiroshi,
Huiping Lu,
Ruggiero Renato,
Hooper Timothy L.,
Baars Menno,
Devireddy Chandan,
Stephenson Larry W.
Publication year - 1991
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.1991.6.1s.145
Subject(s) - medicine , ventricle , heart failure , skeletal muscle , cardiology , latissimus dorsi muscle , stroke (engine) , stroke volume , cardiomyoplasty , surgery , ejection fraction , mechanical engineering , engineering
Our most recent work on cardiac assist with canine latissimus dorsi muscle in a skeletal muscle ventricle (SMV) configuration is reported here. One animal's SMV has been pumping blood effectively in the circulation for more than 16 months. To date there is no evidence of thromboembolism, and the dog has suffered no untoward effects. It has recently been shown, in a mock circulation study, that canine SMVs are capable of developing stroke work, at physiological preloads, much greater than that of the right ventricle and equivalent to that of the left ventricle. The improved ability of conditioned SMVs to perform work, independent of the circulation, during severe hypotension is also demonstrated. In the face of a 75% drop in left ventricular stroke work, the SMV stroke work dropped by only 50%. The continuing work on this subject suggests that a skeletal muscle ventricle may have the potential of becoming a viable alternative in the treatment of heart failure.