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Fate of mild‐to‐moderate bicuspid aortic valve disease untreated during ascending aorta replacement
Author(s) -
Verzini Alessandro,
Bargagna Marta,
Ascione Guido,
Sala Alessandra,
Carino Davide,
Del Forno Benedetto,
Blasio Andrea,
Ruggeri Stefania,
Castiglioni Alessandro,
Alfieri Ottavio,
De Bonis Michele
Publication year - 2021
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.15465
Subject(s) - medicine , bicuspid aortic valve , ascending aorta , stenosis , regurgitation (circulation) , cardiology , aortic valve replacement , aortic valve , aortic valve stenosis , confidence interval , valve replacement , surgery , aorta
Background Bicuspid aortic valve (BAV) is the most common congenital heart defect and it is responsible for an increased risk of developing aortic valve and ascending aorta complications. In case of mild to moderate BAV disease in patients undergoing supracoronary ascending aorta replacement, it is unclear whether a concomitant aortic valve replacement should be performed. Methods From June 2002 to January 2020, 75 patients with mild‐to‐moderate BAV regurgitation (±mild‐to‐moderate stenosis) who underwent isolated supracoronary ascending aorta replacement were retrospectively analyzed. Clinical and echocardiographic follow‐up was 100% complete (mean: 7.4 ± 3.9 years, max: 16.4). Kaplan–Meier estimates were employed to analyze long‐term survival. Cumulative incidence function (CIF) for time to reoperation, recurrence of aortic regurgitation (AR) ≥3+ and aortic stenosis (AS) greater than moderate, with death as competing risk, were computed. Results There was no hospital mortality and no cardiac death occurred. Overall survival at 12 years was 97.4 ± 2.5%, 95% confidence interval (CI: 83.16–99.63). At follow‐up there were no cases of aortic root surgery whereas three patients underwent AV replacement. At 12 years the CIF of reoperation was 2.6 ± 2.5%, 95% CI [0.20–11.53]. At follow‐up, AR 3+/4+ was present in 1 pt and AS greater than moderate in 3. At 12 years the CIF of AR more than 2+/4+ was 5.1 ± 4.98% and of AS more than moderate 6.9 ± 3.8%. Conclusions In our study mild to moderate regurgitation of a BAV did not do significantly worse at least up to 10 years after isolated supracoronary ascending aorta replacement.