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Preoperative level of neutrophil‐lymphocyte ratio: Comparison between cyanotic and acyanotic congenital heart disease
Author(s) -
Manuel Valdano,
Miana Leonardo Augusto,
Solla Davi J. Fontoura,
Fernandes Natália,
Carrillo Gabriel,
Jatene Marcelo Biscegli
Publication year - 2021
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.15413
Subject(s) - medicine , interquartile range , tetralogy of fallot , neutrophil to lymphocyte ratio , heart disease , cardiology , retrospective cohort study , cardiopulmonary bypass , cohort , surgery , lymphocyte
Abstract Introduction Elevated neutrophil‐lymphocyte ratio (NLR) has been associated with poorer outcomes in children undergoing congenital heart surgery under cardiopulmonary bypass (CPB). Objective To compare preoperative NLR levels between cyanotic and acyanotic children undergoing surgical repair with CPB. Methods We performed a retrospective cohort study in 60‐paired children (30 with tetralogy of Fallot [TOF] and 30 with ventricular septal defect [VSD]) between January 2018 and December 2019 matched by age, weight, and gender. Preoperative NLR was measured from the last complete blood count test before the surgery. All of them had negative viral screening. Results The median age in VSD children was 9.5 months (interquartile range [IQR]: 5–12), weight 7 kg (IQR: 5.5–8.7), 19 (63%) was female, and NLR was 0.45 (IQR: 0.3–0.65). The median age in TOF children was 8.5 months (IQR: 5–12), weight 7.6 kg (IQR: 5.8–8.7), 16 (53%) were female, and NLR was 0.67 (IQR: 0.41–1.1). Demographic parameters did not show any statistically significant difference between groups ( p > .05). Children with TOF had higher preoperative NLR compared with VSD patients ( p = .004). As lower O 2 saturation as higher the NLR ( p = .005). Conclusion The preoperative level of NLR was higher in cyanotic congenital heart disease patients.