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Presence of fragmented QRS is associated with left ventricular systolic dysfunction after surgery in patients with severe aortic regurgitation
Author(s) -
Celik Mehmet,
Yilmaz Yusuf,
Karagöz Ali,
Kahyaoglu Muzaffer,
Kup Ayhan,
Celik Fatma Betul,
Izci Servet,
Candan Ozkan,
Gecmen Cetin,
Kirma Cevat,
Kirali Mehmet Kaan
Publication year - 2021
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.15370
Subject(s) - medicine , cardiology , ejection fraction , qrs complex , diastole , regurgitation (circulation) , aortic valve replacement , heart failure , blood pressure , stenosis
Background and Aim of the study Chronic severe aortic regurgitation (AR) is associated with progressive accumulation of interstitial fibrosis and disruption of myocardial structure. After aortic valve replacement (AVR), the negative remodeling process reverses, and left ventricular ejection fraction (LVEF) improves but not in all patients. In this study, we aimed to investigate the association of fragmented QRS (F‐QRS), which is a possible marker of myocardial fibrosis, with postoperative left ventricular (LV) systolic dysfunction. Methods A total of 147 consecutive patients with AVR were included in this study. F‐QRS was identified by the presence of various RSR' patterns (QRS duration <120 ms) such as additional R wave (R prime)or notching of the R or S wave in at least two consecutive leads. Patients were compared in two groups based on the presence or absence of F‐QRS. A logistic regression model was used to determine independent predictors of postoperative LV systolic dysfunction (LVEF <50%). Results Patients with F‐QRS were associated with poor recovery of LV systolic function after AVR compared to the patients without F‐QRS, regardless of preoperative LVEF ( p = .008). F‐QRS was found to be an independent predictor of postoperative LV systolic dysfunction (LVEF <50%). Lower preoperative LVEF and increased LV end diastolic diameter index were also found as independent risk factors for postoperative LV systolic dysfunction. Conclusions As a possible marker of myocardial fibrosis, F‐QRS was associated with postoperative LV systolic dysfunction. Therefore, as a simple and convenient clinical parameter, F‐QRS may be used to predict poor recovery of LVEF after AVR.