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Role of extracorporeal membrane oxygenation in COVID‐19: A systematic review
Author(s) -
Haiduc Ana Alina,
Alom Samiha,
Melamed Naomi,
Harky Amer
Publication year - 2020
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.14879
Subject(s) - extracorporeal membrane oxygenation , medicine , data extraction , systematic review , cochrane library , covid-19 , medline , intensive care medicine , narrative review , meta analysis , disease , surgery , pathology , infectious disease (medical specialty) , political science , law
Objective We aimed to examine the literature evidence behind using extracorporeal membrane oxygenation in COVID‐19 patients in a systematic review manner. Methods We conducted a systematic review using Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) guidelines. A comprehensive literature search was conducted on Global Health Medline, EMBASE, and Cochrane databases using keywords and MeSH terms to identify articles pertaining to extracorporeal membrane oxygenation (ECMO) and Coronavirus disease 2019 (COVID‐19). A narrative synthesis was then undertaken to identify the key themes. Results A total of 25 articles met the inclusion criteria of this systematic review. Three main themes were identified following the data extraction: (a) evidence against/inconclusive regarding ECMO for COVID‐19, (b) evidence supporting ECMO for COVID‐19, and finally (c) VV‐ECMO and VA‐ECMO. After combining the data, there were 3428 patients diagnosed with COVID‐19 and 95 ECMO‐associated deaths (19.83%). Conclusion Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes. Although ECMO has been shown to be beneficial in a selected group of patients, the recuperative effects of ECMO remain inconclusive. We must ensure that risk‐benefit analysis for each candidate is conducted thoroughly so that patients that have increased probability of survival can benefit from this scarce resource.