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Surgical results and pathological analysis of cardiac fibroma in the adolescent and the adult
Author(s) -
Yuan Xin,
Li Baotong,
Yang Yan,
Wang Hongyue,
Sun Hansong,
Song Yunhu,
Wang Wei
Publication year - 2020
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.14790
Subject(s) - medicine , pathological , fibroma , young adult , cardiac tumors , biomarker , cardiac surgery , cardiology , diastole , pathology , blood pressure , biochemistry , chemistry
Backgrounds Disparities may exist between the adolescent and the adult patients with cardiac fibromas in the symptoms, surgical outcomes, and pathological characteristics. The aim of this study was to compare short and midterm surgical outcomes of cardiac fibromas and to compare the biomarker expressions of tumor tissue samples between the adult and the adolescent. Methods Consecutive patients with the diagnosis of cardiac fibroma were admitted and received surgeries. Primary outcomes included in‐hospital mortality, low cardiac output, and readmission due to heart failure. The expression of PCNA and Ki67, two widely adopted indicators of cell proliferation, were evaluated in tissue samples. Results A total of five adolescent patients and five adult patients diagnosed as cardiac fibroma were admitted and given surgeries. When compare with the adults, the adolescent patients were more likely to present symptoms on admission ( P = .048). Postoperative low cardiac output syndrome was significantly higher in the adolescents than in the adults (80.0% vs 0.0, P = .048). The tumor volume relative to ventricular end diastolic diameter had good discriminative ability for low cardiac output (c statistics: 0.96). Pathologically, the percentage of PCNA‐positive cell nuclei was significantly higher in the adolescents than in the adults (36.04% ± 10.54% vs 4.15% ± 3.93%, P = .001). However, there were no Ki67‐positive nuclei in the 10 cases. Conclusions In the current study, we found that postoperative low cardiac output was more likely to occur in the adolescent patients than in the adult patients. When compared with the adult patients, significantly more PCNA‐positive nuclei were observed in the adolescents.