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Safety of thrombolytic therapy in patients with prosthetic heart valve thrombosis who have high international normalized ratio levels
Author(s) -
Farzaneh Khadijeh,
Mortazavi Seyedeh Hamideh,
Oraii Alireza,
Abbasi Kyomars,
Salehi Omran Abbas,
Ahmadi Tafti Seyed Hossein,
Bozorgi Ali,
Kazemi Saeed Ali,
Salarifar Mojtaba,
Sadeghian Saeed
Publication year - 2020
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.14777
Subject(s) - medicine , thrombosis , cardiology , heart valve
Background and Aim Prosthetic valve thrombosis (PVT) is a rare but life‐threatening complication of heart valve replacement. Based on the current guidelines, the treatment of a large number of these patients could be performed through the administration of thrombolytic agents. In the present study, we aim to assess the safety of thrombolytic therapy in patients with PVT who have high international normalized ratio (INR) levels. Methods In this study, we retrospectively analyzed outcomes of thrombolytic therapy in 65 PVT patients with different levels of INR at the time of fibrinolysis at a tertiary cardiac center. Results Mean age of patients was 51.6 ± 12.47 years. The tricuspid valve was the most common site of prosthetic valve thrombosis (64.6%). The Median (range) of INR was 2.1 (0.9‐4.9). The majority of patients (50.8%) achieved a complete response following thrombolytic treatment. There were no cases of intracranial hemorrhage. Other major and minor bleedings occurred in 3 (4.6%) and 10 (15.4%) patients, respectively. No embolic stroke and systemic embolism were observed. We found no significant difference in the frequency of major ( P ‐value = .809) and minor ( P ‐value = .483) bleeding as well as response to thrombolytic therapy ( P ‐value = .658) between patients with different levels of INR. Total administered dose of Streptokinase was also similar in PVT patients with or without major ( P ‐value = .467) and minor ( P ‐value = .221) bleeding complications. Conclusions We concluded that there was no significant difference between PVT patients presenting with subtherapeutic and high INR levels who received thrombolytic treatments regarding both minor and major bleeding complications as well as response to thrombolysis.