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Comparison of the effect of 80 vs 40 mg atorvastatin in patients with isolated coronary artery bypass graft surgery: A randomized clinical trial
Author(s) -
Shekari Arash,
Forouzannia Seyed K.,
Davarpasand Tahereh,
Talasaz Azita H.,
Jalali Arash,
Gorabi Amrita M.,
LotfiTokaldany Masoumeh,
Bagheri Jamshid
Publication year - 2019
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.14100
Subject(s) - medicine , atorvastatin , troponin complex , randomized controlled trial , troponin t , cardiology , artery , coronary artery bypass surgery , creatine , creatine kinase , troponin , anesthesia , surgery , myocardial infarction
Objectives Atorvastatin can decrease cardiac injury after coronary artery bypass graft (CABG) surgery. We compared the effects of 80 and 40 mg of atorvastatin per day on the levels of cardiac troponin T (cTnT) and creatine kinase‐MB (CK‐MB) after an isolated CABG. Methods This randomized single‐blind parallel clinical trial enrolled 125 patients (mean age = 60.59 ± 8.37 years) who were candidates for elective isolated CABG at the Tehran Heart Center between May 2017 and December 2017. Patients were randomly allocated into two groups to receive either 80 mg (n = 62) or 40 mg of atorvastatin (n = 63) per day, 5 days before surgery. The levels of cTnT and CK‐MB, used as myocardial injury markers, were measured at baseline and then at 8 and 24 hours after CABG. Results The levels of CK‐MB and cTnT at baseline and at 8 and 24 hours following CABG were not significantly different between the two groups. Our repeated measures analysis of variance showed that the levels of CK‐MB and cTnT increased significantly over time ( P < .001). No significant interaction was observed between time and the atorvastatin dosage on the levels of either CK‐MB ( P = .159) or cTnT ( P = .646). In addition, the between‐group effects were not significant for CK‐MB ( P = .632) and cTnT ( P = .126). Conclusion The higher dose of atorvastatin (80 mg) did not exert a more protective effect than the standard dose of atorvastatin (40 mg) after CABG surgery.