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The current status of stem cell therapy in ischemic heart disease
Author(s) -
Michler Robert E.
Publication year - 2018
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.13789
Subject(s) - medicine , stem cell , paracrine signalling , stem cell therapy , cell therapy , clinical trial , bone marrow , bone marrow stem cell , disease , immunology , cancer research , microbiology and biotechnology , pathology , mesenchymal stem cell , biology , receptor
The last decade has witnessed the publication of a number of stem cell clinical trials, primarily using bone marrow‐derived cells as the injected cell. Much has been learned through these “first‐generation” clinical trials. The advances in our understanding include (1) cell therapy is safe; (2) cell therapy has been mildly effective; and (3) human bone marrow‐derived stem cells do not transdifferentiate into cardiomyocytes or new blood vessels. The primary mechanism of action for cell therapy is now believed to be through paracrine effects that include the release of cytokines; chemokines; and growth factors that inhibit apoptosis and fibrosis, enhance contractility, and activate regenerative mechanisms through endogenous circulating or site‐specific stem cells. The current direction for clinical trials includes the use of stem cells capable of cardiac lineage.