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Acute humoral rejection in an infant without risk factors after heart transplantation
Author(s) -
Binsalamah Ziyad M.,
Marcano Juan,
ZeaVera Rodrigo,
Tunuguntla Hari,
Kearney Debra L.,
Heinle Jeffrey S.,
Fraser Charles D.,
Mery Carlos M.
Publication year - 2018
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.13532
Subject(s) - medicine , heart transplantation , transplantation , humoral immunity , panel reactive antibody , dilated cardiomyopathy , immune system , graft rejection , antibody , risk factor , immunology , cardiology , heart failure , kidney transplantation
Graft rejection is the most common factor that limits graft survival after transplantation. During infancy, the humoral immune system is partially suppressed and humoral rejection of a cardiac allograft has not been reported in the absence of risk factors such as prior transplantation, blood transfusions, ventricular assist devices, and elevation of panel reactive antibodies. We present a case of an infant with dilated cardiomyopathy who developed multiple episodes of acute humoral rejection after heart transplantation in the absence of risk factors.