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Replacement therapy for coronary artery bypass surgery in patients with hemophilia A and B
Author(s) -
Kanellopoulou Theoni,
Nomikou Efrosyni
Publication year - 2018
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.13530
Subject(s) - medicine , cardiopulmonary bypass , surgery , artery , coronary artery bypass surgery , bolus (digestion) , coagulation , anesthesia
There are only a few cases of patients with hemophilia A and B who have undergone coronary artery bypass surgery. High levels of replacement therapy with factor concentrate either with bolus or continuous infusion are usually required pre‐operatively and during the first post‐operative days in order to maintain the coagulation deficient factor levels greater than 80% of normal. Heparinization during cardiopulmonary bypass appears to be safe and intra‐operative blood salvage using cell saver techniques reduce the need for transfusions.