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Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose‐Alpha‐1,3‐Galactose
Author(s) -
Hawkins Robert B.,
Frischtak Helena L.,
Kron Irving L.,
Ghanta Ravi K.
Publication year - 2016
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.12764
Subject(s) - medicine , degeneration (medical) , allergy , cardiology , aortic valve , alpha (finance) , surgery , pathology , immunology , construct validity , patient satisfaction
We present the cases of two patients with bioprosthetic aortic valves who developed an allergy to alpha‐gal. Each had premature degeneration of their bioprosthesis and demonstrated rapidly increasing transvalvular gradients after development of their allergy. Each underwent successful replacement with a mechanical aortic valve within 1–2 years of symptom onset. doi: 10.1111/jocs.12764 (J Card Surg 2016;31:446–448)